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125 I-labeled monoclonal antibodies ( 125 I-mAbs) can efficiently treat small solid tumors. Here, we investigated the role of apoptosis, autophagy and mitotic catastrophe in 125 I-mAb toxicity in p53 −/− and p53 +/+ cancer cells.We exposed p53 −/− and p53 +/+ HCT116 cells to increasing activities of internalizing (cytoplasmic location) anti-HER1...
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