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Labeling derivatives of dihydrotetrabenazine (DTBZ) with F-18 (T 1/2 =110 min) instead of C-11 (T 1/2 =20 min) would improve their utility and availability for imaging vesicular monoamine transporters (VMAT2) in clinical settings. The successful synthesis, reported previously, of two novel 9-fluoroalkyl(±)-DTBZ ligands prompted us to study the optically resolved active ligand 9-fluoropropyl-(+)-DTBZ...
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