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Cholangiocarcinoma in northeast Thailand is associated with liver fluke infection. Mechanisms of inactivation of the p15 INK4b , p16 INK4a , and p14 ARF have been reported in many human cancers but have not hitherto been studied in liver fluke–related cholangiocarcinoma, particularly genetic and epigenetic effects on protein expression. We investigated loss of heterozygosity...
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