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Freund's complete adjuvant (FCA)-induced arthritis is a commonly used model in the rat. Use of FCA to induce arthritis in mice has been only occasionally reported, and most attempts to use this model have met with little success. Subdermal injection of FCA at multiple sites around the tibiotarsal joint of male C57Bl6 mice caused a localised inflammatory reaction to develop in 24 h. Significant swelling...
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