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Chronic obstructive pulmonary disease (COPD) is a serious and mounting global public health problem. Although its pathogenesis is incompletely understood, chronic inflammation plays an important part and so new therapies with a novel anti-inflammatory mechanism of action may be of benefit in the treatment of COPD. Cilomilast and roflumilast are potent and selective phosphodiesterase (PDE)4 inhibitors,...
A large-scale prospective study was conducted in 3810 Japanese elderly (⩾65 years old) patients with asthma or chronic obstructive pulmonary disease (COPD) who had been treated with sustained-release theophylline tablets (THEODUR ® ) at a dose of 400mg/day for 1–6 months, in principle.Among 3798 protocol-complying patients (mean age: 73.8±0.10 years, 1997 with COPD), 261 theophylline-related...
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