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The physiopathology of radiation-induced bone damage is no completely elucidated. Ionizing radiation may induce an inhibition or an impairment of growing bone. This fact is of particular importance in children, and represents one of the most important dose-limiting factors in the radiotherapeutic management of children with malignant diseases. Scoliosis, epiphyseal slippage, avascular necrosis,...
Several experimental studies on animals have yielded to the tolerance single doses for different critical organs. Anatomical alterations are located essentially in the intima of the arteries with oedema, histio-lymphoplasmocytoid infiltration in a first time leading toarterial obstructions and necrosis after the 6th week. These radiation injuries are related to the IORT dose, the target volume and...
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