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High doses of ionizing radiation (> 40 Gy) cause severe lung fibrosis in approximatitely 5% of the cases. There is a twofold increase when chemotherapy is added to ionizing radiation. Lung fibrosis is due to the destruction of lung tissue by ionizing radiation but also to various cytokine effects (PDGF-β, TGF-β). Only a minority of patients (approximatitely 10%) with abnormal X-rays will experience...
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