Neuroplasticity is the panacea of neuropsychiatry, changing ‘bad behaviour’ patterns and experiences into ‘good behaviour’ patterns and people will then ‘live happily ever after’ i.e., Pollyanna however, to paraphrase Star Wars, there is always ‘the dark side’ of neuroplasticity: including epilepsy, addiction, chronic pain, allodynia and complex regional pain syndromes. Neuroplasticity is being explored extensively to promotive recovery from brain trauma, spinal injury.This is a brief review of the literature in neuoplasticity of epilepsy and psychiatry and the discussion of the neurobehavioral treatment of epilepsy.Case presentation of two patients: John Doe and Richard Roe, one of whom has been extensively investigated at numerous first rate neurological institutions, and the second who has been also extensively investigated. They will both be treated with a variant of the Andrews-Reiter approach. John Doe has three epileptiform foci: two in the left frontal and temporal regions and one in the right temporal region. Richard Roe had a significant head trauma and a 3D SPECT scan showing significant hypoperfusion of the temporal lobes and prefrontal cortex but over-activity in the thalami and basal ganglia. He has frequent intractable panic attacks whose symptoms overlap with those of complex partial seizures despite a negative workup. Both patients have been thoroughly evaluated by a competent neurologist/epileptologist and a neuropsychiarist.The response of either patient to therapy using this approach is not yet known. They are being treated with the usual pharmacological AEDs.Neuroplasticity is a major phenomenon in neuroscience. How effective the Andrews Reiter approach will be in these two subjects is not yet known but certainly neuoplasticity and neuroneogenesis is a major field of investigation.