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The application of FTIR ATR (Fourier transform infrared attenuated total reflection), DRIFT (diffuse reflectance infrared Fourier transform) and FT Raman spectroscopy for the quantification of thiamine hydrochloride, or vitamin B1, in tablets was compared. PLS (partial least squares) calibration models were built and validated using the spectra of 40 samples containing vitamin B1 and excipients. To...
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