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Studies in our laboratory have demonstrated that addition of polyanions, heparin or dextran sulfate, to endothelial cell cultures decrease free radical injury. To determine if these polyanions had a similar effect on cardiomyocytes, models of free radical injury were produced in adult rat cardiomyocyte cultures by: (1) addition of hydrogen peroxide; (2) exposure to hypoxia followed by reoxygenation;...
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