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Compromised SERCA 2a activity is a key malfunction leading to the Ca 2+ cycling alterations in failing human myocardium. SERCA 2a activity is regulated by the Ca 2+ /calmodulin-dependent protein kinase (CaM-kinase) but alterations of the CaM-kinase pathway regarding SERCA 2a in heart failure are unresolved. Therefore we investigated the CaM-kinase and phosphatase calcineurin mediated...
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