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Among the players involved in Ca 2+ homeostasis in heart tissue are SERCA (sarco/endoplasmic reticulum Ca 2+ ATPase)-type Ca 2+ pumps. Until recently, human heart was known to coexpress major SERCA2a and minor SERCA2b isoforms. Here, we will summarize data showing that nonfailing human heart is equipped with an increasing variety of SERCA isoforms comprised new SERCA2 (ATP2A2)...
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