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The sustained positive inotropic effect of α-adrenoceptor agonists in the heart is associated with a small increase in intracellular Ca 2+ transients together with a larger sensitization of myofilaments to Ca 2+ . The multifunctional Ca 2+ and calmodulin-dependent protein kinase II (CaMKII) could contribute to this effect, either by affecting the Ca 2+ release (ryanodine...
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