This work is aimed to join the explosion-bonded CP-Ti/X65 bimetallic sheets with Cu-based flux-cored wires. Tungsten-inert gas (TIG) welding method was applied. The effect of V ratio on microstructure and mechanical properties was investigated. Ti–Fe, Ti–Cu and Ti–Cu–Fe intermetallics were identified in the reaction zones. The results showed that enhancing V ratio in the flux-cored wires led to the extension of the reaction zones, which eventually decreased the crack susceptibility of the joints. With V ratio rising to 25wt.%, a sound joint was obtained. The ultimate strength of the joints fit the requirements. However, the bend tests showed extremely low bend ductility. Enhancing V ratio in the filler metals allowed diluting but not suppressing the formation of brittle intermetallics.