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Lindberg, B. F., E. Gyllstedt and K.-E. andErsson. Conversion of angiotensin I to angiotensin Ii by chymase activity in human pulmonary membranes. Peptides 18(6) 847–853, 1997.—An aprotinin-insensitive, angiotensin II (Ang II)-forming chymase has recently been identified in human heart tissue. We studied the hydrolysis of Ang I in human lung membranes. The hydrolysis products Ang II, Ang III, Ang-(1–9),...
de With, N. D., K. W. Li, C. R. JimÉNez, N. Vonk, K. Dreisewerd, F. Hillenkamp, M. Karas and W. P. M. Geraerts. Intracellular degradation of C-peptides in molluscan neurons producing insulin-related hormones. Peptides 18(6) 765–770, 1997.—Single Light Green Cells (LGC) of Lymnaea stagnalis, expressing four genes encoding insulin-related peptides (MIPs) and C-peptides, and sections from the median...
Lesser, W., S. W. P. Falconer and G. A. Cottrell. Actions of Fmrfamide-related peptides on the gCa2+ of the C1 neuron in Helix aspersa. Peptides 18(6) 909–911, 1997.—The endogenous neuropeptides FMRFamide and FLRFamide (tetrapeptides) reversibly reduced a voltage-activated calcium current in the C1 neuron of Helix aspersa by an average of 20%. Two structurally related heptapeptides, pQDPFLRFamide...
Bhargava, H. N., Y.-J. Cao and G.-M. Zhao. Effect of 7-nitroindazole on tolerance to morphine, U-50,488H and [D-Pen2, D-Pen5]enkephalin in mice. Peptides 18(6) 797–800, 1997.—The effects of 7-nitroindazole (7-NI), an inhibitor of the neuronal nitric oxide synthase (nNOS) which does not increase blood pressure, on tolerance to the antinociceptive activity of μ-(morphine), κ-(U-50,488H) and β-([d-Pen...
Erin, N., B. Ç. Yegen and S. Oktay. The protective effect of 5-Ht3 receptor antagonist in thyrotropin releasing hormone-induced gastric lesions. Peptides 18(6) 893–898, 1997. The present study examined 1) oxidative stress and gastric lesions induced by thyrotropin releasing hormone (Trh) 2) The effect of a 5-hydroxytrypthamine3 (5-Ht3) receptor antagonist, Ics 205930 on protective effect of calcitonin...
PENG, P.-J., U. G. SAHM, R. V. M. DOHERTY, R. G. KINSMAN, S. H. MOSS AND C. W. POUTON.Binding and biological activity of C-terminally modified melanocortin peptides: A comparison between their actions at rodent MC 1 and MC 3 receptors.PEPTIDES 18(7) 1001–1008, 1997.—Five subtypes of melanocortin receptors have to date been identified, but to date little is known about the different...
EDISON, A. S., L. A. MESSINGER AND A. O. W. STRETTON.afp-1: A gene encoding multiple transcripts of a new class of FMRFamide-like neuropeptides in the nematode Ascaris suum.PEPTIDES 18(7) 929–935, 1997.—We have identified a gene, afp-1, that encodes a new subfamily of six FMRFamide-like neuropeptides in the nematode Ascaris suum. The predicted peptides share the C-terminal sequence PGVLRF-NH 2...
FRANCI, C. R., J. A. ANSELMO–FRANCI AND S. M. McCANN.Angiotensinergic neurons physiologically inhibit prolactin, growth hormone and thyroid-stimulating hormone, but not adrenocorticotropic hormone, release in ovariectomized rats.PEPTIDES 18(7) 971–976, 1997.—Angiotensin II (AII)-containing neurons with cell bodies in the rostral medial hypothalamus and axons project to the external layer of the median...
CARBONE, A., A. C. SCHLOITHE, J. R. HARVEY, R. A. BAKER AND G. T. P. SACCONE.Gastrin-releasing peptide stimulates possum gallbladder contractility in vitro.PEPTIDES 18(7) 1067–1071, 1997.—Reports of the action of gastrin-releasing peptide (GRP) on gallbladder contraction are limited to a few species. We compared the action of GRP, acetyl gastrin-releasing peptide 20–27 (GRP 20–27), and cholecystokinin-octapeptide...
North, W. G., M. J. Fay, K. Longo and J. Du.Functional vasopressin V 1 type receptors are present in variant as well as classical forms of small-cell carcinoma.PEPTIDES 18(7) 985–993, 1997.—Vasopressin and other neuropeptides are believed to serve as autocrine growth factors for small-cell carcinoma of the lung (SCCL), and these mitogenic influences are reported to involve increases in intracellular...
OWEN, D. B., J. S. MORLEY, D. M. ENSOR, Y. S. ALLEN AND J. B. MILES.Trophic effects of melanotropin-potentiating factor (MPF) on cultures of cells of the central nervous system.PEPTIDES 18(7) 1015–1021, 1997.—MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show...
KNIGGE, K. M. AND J. E. WAGNER.Melanin-concentrating hormone (MCH) involvement in pentylenetetrazole (PTZ)-induced seizure in rat and guinea pig. PEPTIDES 18(7) 1095–1097, 1997.—Intraperitoneal injection of 60 mg/kg of pentylenetetrazole (PTZ) induced seizure in rats, but was subthreshold and did not result in seizure in guinea pigs. Three days after intracerebroventricular (ICV) injection of 75 μg...
FACCHINETTI, F., D. RADI, G. MOSCONI, O. CARNEVALI, M. PESTARINO AND A. M. POLZONETTI-MAGNI.Acetyl salmon endorphin-like immunoreactivity in the ovary of two teleostean species: changes with environmental conditions.PEPTIDES 18(7) 957–963, 1997.—The presence of salmon acetylated endorphin (acetyl sEP) in the ovary of seabream and sea bass was investigated through immunocytochemical and biochemical...
WEISINGER, R. S., J. R. BLAIR-WEST, P. BURNS, D. A. DENTON AND E. TARJAN.Role of brain angiotensin in thirst and sodium appetite of rats.PEPTIDES 18(7) 977–984, 1997.—The role of brain angiotensin II (ANG II) in water, Na and food intake of rats was studied. Intracerebroventricular (ICV) infusion (100 μg/h) of the non-peptide ANG II receptor antagonist losartan (type 1), but not PD123319 (type 2),...
SANDIN, J., K. TAN-NO, L. KASAKOV, I. NYLANDER, A. WINTER, J. SILBERRING AND L. TERENIUS.Differential metabolism of dynorphins in substantia nigra, striatum, and hippocampus.PEPTIDES 18(7) 949–956, 1997.—To map the proteolytic enzymes metabolizing dynorphins in brain structures, size-exclusion chromatography linked to electrospray ionization mass spectrometry was used. Enzymes extracted from rat hippocampus,...
SUNDBLOM, D. M., E. KALSO, I. TIGERSTEDT, K. WAHLBECK, P. PANULA AND F. FYHRQUIST.Neuropeptide FF-like immunoreactivity in human cerebrospinal fluid of chronic pain patients and healthy controls.PEPTIDES 18(7) 923–927, 1997.—Neuropeptide FF (NPFF) is a neuropeptide with some antiopioid characters found in several mammalian species. In human brain it might be an important pain-regulating peptide. Using...
MURTHY, S., V. P. DINOSO, JR. AND R. NATRAJAN.Neurohormonal mechanisms of cigarette smoke-induced duodenal mucosal bicarbonate secretion in the rat.PEPTIDES 18(7) 1061–1066, 1997.—The effect of cigarette smoke and nicotine on duodenal mucosal bicarbonate secretion (DMBS) was studied in rats. Cigarette smoke but not intravenous nicotine administered acutely to anesthetized rats via a tracheostomy tube...
JONES, D. A., A. J. MacLELLAN, J. CUMMINGS, A. A. RITCHIE, S. P. LANGDON AND J. F. SMYTH. Processing of [d-arg 1 ,d-Phe 5 ,d-Trp 7,9 ,Leu 11 ]substance P in xenograft bearing Nu/Nu mice. PEPTIDES 18(7) 1073–1077, 1997.—[d-Arg 1 ,d-Phe 5 ,d-Trp 7,9 ,Leu 11 ]Substance P is a broad-spectrum neuropeptide growth factor antagonist that has...
AU, C. L., B. J. CANNY, P. G. FARNWORTH AND A. S. GIRAUD.Bombesin regulation of adrenocorticotropin release from ovine anterior pituitary cells.PEPTIDES 18(7) 995–1000, 1997.—Mammalian members of the bombesin-like peptide family (gastrin releasing peptides; GRP) have been localized in the ovine median eminence and in hypophysial-portal blood, suggesting a role in the regulation of anterior pituitary...
NUSSDORFER, G. G., G. P. ROSSI AND G. MAZZOCCHI.Role of adrenomedullin and related peptides in the regulation of the hypothalamo–pituitary–adrenal axis.PEPTIDES 18(7) 1079–1089, 1997.—Adrenomedullin (ADM) is a hypotensive peptide, originally isolated from human pheochromocytomas, and then found to be widely distributed in the various body systems. ADM derives from preproadrenomedullin, a 185-amino...
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