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SchiÖth, H. B., R. Muceniece and J. E. S. Wikberg. Selectivity of [Phe-I7], [Ala6], and [d-Ala4,Gln5,Tyr6] substituted ACTH(4-10) analogues for the melanocortin receptors. Peptides 18(5), 761-763, 1997.—We tested [Ala6]ACTH(4-10) and [Phe-I7]ACTH(4-10) (putative MC receptor antagonists), [d-Ala4, Gln5,Tyr6]ACTH(4-10) (BIM 22015), and ACTH(4-10) with radioligand binding using transiently expressed...
Matsuda, K., Y. Takei, J.-I. Katoh, S. Shioda, A. Arimura and M. Uchiyama. Isolation and structural characterization of pituitary adenylate cyclase activating polypeptide (PACAP)-like peptide from the brain of a teleost, stargazer, Uranoscopus japonicus. Peptides 18 (5) 723–727, 1997.—Pituitary adenylate cyclase-activating polypeptide (PACAP) is a novel neuropeptide consisting of 38-residue (PACAP...
Azizeh, B. Y., B. A. Van Tine, D. Trivedi and V. J. Hruby. Pure glucagon antagonists: Biological activities and cAMP accumulation using phosphodiesterase inhibitors. Peptides 18(5) 633–641, 1997.— Five new glucagon analogues have been designed, synthesized, characterized and their biological activities tested. The investigation was centered on modifications in the N-terminal region in particular,...
HÖRsch, D., R. Day, N. G. Seidah, E. Weihe and M. K.-H. SchÄFer. Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal. Peptides 18(5) 755–760, 1997.—The distribution of prohormone/pro-peptide convertases PC1/PC3 and PC2 was investigated in the human anal canal by immunohistochemistry. Both prohormone convertases exhibited region-specific distribution...
Arvat, E., L. Di Vito, B. Maccagno, F. Broglio, M. F. Boghen, R. Deghenghi, F. Camanni and E. Ghigo. Effects of Ghrp-2 and Hexarelin, two synthetic Gh-releasing peptides, on Gh, prolactin, Acth and cortisol levels in man. Comparison with the effects of Ghrh, Trh and hCrh. Peptides 18(6) 885–891, 1997.—GHRP-2 (d-Ala-d-βNal-Ala-Trp-d-Phe-Lys-NH2) and Hexarelin (HEX) (His-d-2-methylTrp-Ala-Trp-dPhe-Lys-NH...
Merani, S., R. M. Palmour, J. Bradwejn, I. Berezowska, F. J. Vaccarino and J. Gutkowska. Development of a sensitive and specific assay system for cholecystokinin tetrapeptide. Peptides 18(6) 869–875, 1997.—Cholecystokinin is a gastrointestinal and neuropeptide which has been implicated in a wide range of physiological and behavioral processes. We have developed a sensitive and specific assay system...
Mulder, H., M. Ekelund, E. Ekblad and F. Sundler. Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects. Peptides 18(6) 771–783, 1997.—The occurrence of islet amyloid polypeptide (IAPP) in the gut and pancreas of several species and during ontogeny of the rat, was studied using immunocytochemistry. Effects of IAPP on rat ileal smooth muscle were assessed...
Ookuma, K., C. Barton, D. A. York and G. A. Bray. Effect of enterostatin and kappa-opioids on macronutrient selection and consumption. Peptides 18(6), 785–791, 1997.—Enterostatin, the activation peptide of pancreatic procolipase, suppresses consumption of high-fat diets and selectively suppresses fat consumption over carbohydrate consumption. Kappa-opioid subtype agonists stimulate feeding whereas...
Czapla, M. A., H. C. Champion and P. J. Kadowitz. Nociceptin, an endogenous ligand for the Orl1 receptor, has vasodilator activity in the hindquarters vascular bed of the rat. Peptides 18(6) 793–795, 1997.—The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the G-protein coupled, opioid-like receptor ORL1. In the present study, responses to intra-arterial...
Waschek, J. A., V. Lelievre, D. T. Bravo, T. Nguyen and J.-M. Muller. Retinoic acid regulation of the Vip and Pacap autocrine ligand and receptor system in human neuroblastoma cell lines. Peptides 18(6) 835–841, 1997.—Neuroendocrine tumors, neuroblastoma in particular, commonly express the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP)...
Lin, X.-W. and R. E. Peter. Goldfish γ-preprotachykinin mRna encodes the neuropeptides substance P, carassin, and neurokinin A. Peptides 18(6) 817–824, 1997.—Two cDNAs, size 969 bp and 1146 bp respectively, encoding goldfish γ-preprotachykinin (γ-PPT) were identified. Both cDNAs contain the same 345 bp open reading frame. The deduced 114-amino acid γ-PPT contains the sequence of substance P, carassin...
TunÇEl, N., Y. Aydin, M. KoŞAr and M. TunÇEl. The effect of vasoactive intestinal peptide (Vip) on the testicular tissue histamine level of immobilized + cold stressed rats. Peptides 18(6) 913–915, 1997.—The effects of VIP on testicular tissue histamine level of stressed (immobilization and cold) rats were investigated. Sixteen Sprague-Dawley adult male rats were used and divided into three groups...
Hu, Y. and J. C. Dunbar. Regional vascular and cardiac responses to systemic neuropeptide-Y in normal and diabetic rats. Peptides 18(6) 809–815, 1997.—Diabetes is associated with altered autonomic activity, and both the peripheral and central nervous content of NPY is altered in diabetes suggesting that part of the cardiovascular dysfunction of diabetes may be associated with altered responses to...
LindÉN, A., S. Yoshihara, L.-O. Cardell, T. Kaneko, P. StjÄRne and J. A. Nadel. Functional type Ii Vip-Pacap receptors in human airway epithelial-like cells. Peptides 18(6) 843–846, 1997.—VIP-PACAP receptors were characterized in a human airway epithelial-like cell line (Calu-3). Pituitary adenylate cyclase activating polypeptide (PACAP) 1–27, PACAP 1–38, vasoactive intestinal polypeptide (VIP) and...
Labelle, M., Y. Boulanger, A. Fournier, S. St.-Pierre and R. Savard. Tissue-specific regulation of fat cell lipolysis by Npy in 6-Ohda-treated rats. Peptides 18(6) 801–808, 1997.—The effects of neuropeptide Y (NPY), peptide YY (PYY), [Leu31, Pro34]NPY, and NPY(13–36) on adipocyte lipolysis have been studied in subcutaneous (inguinal) and visceral (parametrial) rat adipose tissues. A 48-h fasting period...
Dunlop, J., Y. Zhang and N. Evans. Full and partial agonist activity of C-terminal cholecystokinin peptides at the cloned human Cck-A receptor expressed in Chinese hamster ovary cells. Peptides 18(6) 865–868, 1997.—The agonist activities of the C-terminal cholecystokinin peptides sulfated cholecystokinin octapeptide (CCK-8S), non-sulfated cholecystokinin octapeptide (CCK-8NS), pentagastrin and CCK-4...
Mohri, H. Interaction of fibronectin with integrin receptors: Evidence by use of synthetic peptides. Peptides 18(6) 899-907, 1997.—Recent work on the structure and function of fibronectin and on the important binding sites in fibronectin is summarized.
Koshimura, K., Y. Murakami, M. Mitsushima, T. Hori and Y. Kato. Activation of Na+ channels in Gh3 cells and human pituitary adenoma cells by Pacap. Peptides 18(6) 877–883, 1997.—The effects of pituitary adenylate cyclase activating polypeptide (PACAP) on ion channels were examined in GH3 cells and human pituitary adenoma cells. In GH3 cells, PACAP-38 (10-9 M) reversibly activated tetrodotoxin-sensitive...
Kumar, A., S. Morrison and A. Gulati. Effect of EtA receptor antagonists on cardiovascular responses induced by centrally administered sarafotoxin 6b: Role of sympathetic nervous system. Peptides 18(6) 855–864, 1997.— The present study was carried out to investigate the cardiovascular effects of centrally administered SRT6b in saline, BQ123 and BMS182874 pretreated male Sprague-Dawley rats, using...
Polidori, C., I. Panocka, R. Ciccocioppo, M. Broccardo, G. Improta, D. Regoli and M. Massi. Further evidence that the tachykinin Pg-Kii is a potent agonist at central Nk-3, but not Nk-1, receptors. Peptides 18(6) 825–833, 1997.—Intracerebroventricular (ICV) injection of tachykinins (TKs) inhibits ethanol intake and angiotensin II-induced water intake; the effects are apparently mediated by NK-3 and...
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