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Garreau, I., K. Cucumel, N. Dagouassat, Q. Zhao, A. Cupo and J. M. Piot. Hemorphin peptides are released from hemoglobin by Cathepsin D. radioimmunoassay against the C-part of V-V-hemorphin-7: An alternative assay for the Cathepsin D activity. Peptides 18(2) 293–300, 1997.—In order to investigate the putative physiological role of the in vivo release of hemorphins from hemoglobin in tissues, an immunological...
Yu, W.-Z. and R. J. Bodnar. Interactions between Angiotensin Ii and delta opioid receptor subtype agonists upon water intake in rats. Peptides 18(2) 241–245, 1997.—Delta opioid receptor agonists, like those of mu and kappa receptors, stimulate water intake. To assess the relative contributions of delta1 and delta2 receptors in the modulation of water intake stimulated by Angiotensin II (AII), the...
Shih, C. and G. W. Bernard. Neurogenic substance P stimulates osteogenesis in vitro Peptides 18(2) 323–326, 1997.—Previous studies have shown that there is colocalization of substance P (SP) and calcitonin gene-related peptitde (CGRP)-immunoreactive nerve fibers in bone, periosteum and bone marrow. Because SP may also possibly play a role in bone formation, we decided to test whether it has an osteogenic...
Gonzalez, M. I., V. Kalia, D. R. Hole and C. A. Wilson. α-Melanocyte-stimulating hormone (α-MSH) and melanin-concentrating hormone (MCH) modify monoaminergic levels in the preoptic area of the rat. Peptides 18(3) 387–392, 1997.—The effect of perfusion of melanin-concentrating hormone (MCH) or α-melanocyte-stimulating hormone (α-MSH) (100 ng/μl) in the ventromedial nucleus (VMN) or medial preoptic...
Yasuda-Kamatani, Y., M. Kobayashi, A. Yasuda, T. Fujita, H. Minakata, K. Nomoto, M. Nakamura and F. Sakiyama. A novel d-amino acid-containing peptide, fulyal, coexists with fulicin gene-related peptides in Achatina atria. Peptides 18(3) 347–354, 1997.—Fulicin (Phe-d-Asn-Glu-Phe-Val-NH2) is a neuropeptide from ganglia of the African giant snail (Achatina fulica). Previously, the sequences of nine fulicin...
Takahashi, M., S. Moriguchi, H. Suganuma, A. Shiota, F. Tani, H. Usui, K. Kurahashi, R. Sasaki and M. Yoshikawa. Identification of casoxin C, an ileum-contracting peptide derived from bovine κ-casein, as an agonist for C3a receptors. Peptides 18(3) 329-336, 1997.—Casoxin C (Tyr-Ile-Pro-Ile-Gln-Tyr-Val-Leu-Ser-Arg) is a bioactive peptide that was isolated from a tryptic digest of bovine κ-casein as...
Sanchez, M., B. I. Baker and M. Celis. Melanin-concentrating hormone (MCH) antagonizes the effects of α-MSH and neuropeptide E-I on grooming and locomotor activities in the rat. Peptides 18(3) 393–396, 1997.—The intraventricular (ICV) administration of the neuropeptide melanocyte stimulating hormone (α-MSH) is known to elicit a series of behaviors in the rat which include excessive grooming and other...
Takahashi, K., M. Sone, F. Satoh, O. Murakami, K. Totsune, H. Tanji, N. Sato, H. Ito and T. Mouri. Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid. Peptides 18(3) 459–461, 1997.—The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like...
Balasubramaniam, A. Neuropeptide Y family of hormones: Receptor subtypes and antagonists. Peptides 18(3) 445–457, 1997.—Neuropeptide Y (NPY) is the most abundant peptide present in the mammalian central and peripheral nervous system. NPY exhibits a variety of potent central and peripheral effects including those on feeding, memory, blood pressure, cardiac contractility and intestinal secretions. Classical...
Williams, C. L., G. C. Rosenfeld and T. F. Burks. Cholecystokinin-induced antinociception is not blocked by CCK-A or CCK-B receptor antagonists. Peptides 18(3) 409–414, 1997.—To determine the relative importance of CCK-A, CCK-B, and opioid receptors in mediating the antinociceptive actions of cholecystokinin, we evaluated the actions of selective agonists and antagonists in the mouse hot plate assay...
Schmidt, P. T. and J. J. Holst. Use of antagonists to define tachykininergic control of intestinal motility in pigs. Peptides 18(3), 373–379, 1997.—The involvement of the tachykinins in extrinsic nervous control of motility was studied in isolated, vascularly perfused, porcine ileal segments. Substance P and neurokinin A (10−8M) stimulated motility, and nonpeptide NK1 and NK2 receptor antagonists...
Carrasco, M., M. Del Rio, A. Hernanz and M. De La Fuente. Inhibition of human neutrophil functions by sulfated and nonsulfated cholecystokinin octapeptides. Peptides 18(3) 415–422, 1997.—The effects of CCK-8s and desulfated CCK-8 at concentrations ranging from 10−14 to 10−6M were studied in vitro on several functions of human peripheral neutrophils: adherence to substrate, mobility (spontaneous and...
Conlon, J. M. and U. Aronsson. Multiple bradykinin-related peptides from the skin of the Frog, Rana temporaria. Peptides 18(3) 361–365, 1997.—The skin of the European common frog, Rana temporaria, contains a very high concentration of bradykinin (BK) but the mode of biosynthesis of the peptide is unknown. In addition to BK, we have isolated from an extract of R. temporaria skin the metabolites [des-Arg...
Reich, G., K. E. Doble, D. A. Price and M. J. Greenberg. Effects of cardioactive peptides on myocardial cAMP levels in the snail Helix aspersa. Peptides 18 (3) 355–360, 1997.—Several cardioactive peptides from the pulmonate snail Helix aspersa were tested for their effects on myocardial cAMP levels, but only the family of small cardioactive peptides (SCPs) were clearly effective. SCP increased cAMP...
Zarandi, M., M. Kovacs, J. E. Horvath, K. Toth, G. Halmos, K. Groot, A. Nagy, Z. Kele, and A. V. Schally, Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH). Peptides 18(3) 423–430, 1997.—In the search for more potent antagonists of hGH-RH, 20 new analogs were synthesized, purified and tested in vitro. All the analogs were based on the N-terminal...
Takahashi, K.-I., Y.-C. Liu, N. Hayashi, F. Goto, M. Kato, H. Kawashima and T. Takeuchi. Production of bioactive salmon calcitonin from the nonendocrine cell lines COS-7 and CHO. Peptides 18(3) 439–444, 1997.—To produce bioactive salmon calcitonin from the conventional nonendocrine cell lines, COS-7 and CHO, we devised a salmon calcitonin expression vector by combining the amino-terminus of human...
KovÁCs, M., A. V. Schally, M. ZarÁNdi and K. Groot. Inhibition of GH release in rats by new potent antagonists of growth hormone-releasing hormone (GH-RH). Peptides 18(3) 431–438, 1997.—Biological activity of a new series of potent GH-RH antagonists containing formyl or phenylacetyl group at the N-terminus of the sequence [d-Arg2,Phe(4-Cl)6,Nle27]hGH-RH(1-29)NH2, as well as various substitutions in...
Gourlet, P., P. Vertongen, A. Vandermeers, M.-C. Vandermeers-Piret, J. Rathe, P. De Neef, M. Waelbroeck and P. Robberecht. The long-acting vasoactive intestinal polypeptide agonist RO 25-1553 is highly selective of the VIP2 receptor subclass. Peptides 18(3) 403–408, 1997.—RO 25-1553 is a synthetic VIP analogue that induced a long-lasting relaxation of tracheal and bronchial smooth muscles as well...
Gehlert, D. R., D. A. Schober, S. L. Gackenheimer, L. Beavers, R. Gadski, I. Lundell and D. Larhammar. [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: Evidence for heterogeneity in pancreatic polypeptide receptors. Peptides 18(3) 397–401, 1997.—Cloned receptors for the PP-fold peptides are subdivided into Y1, Y2, PP1/Y4, Y5 and Y6. NPY and PYY have similar affinity...
Mignogna, G., C. Severini, G. Falconieri Erspamer, R. Siciliano, G. Kreil and D. Barra. Tachykinins and other biologically active peptides from the skin of the Costa Rican Phyllomedusid frog Agalychnis callidryas. Peptides 18(3) 367–372, 1997.—Peptides present in a methanol extract prepared from skin of the Costa Rican frog Agalychnis callidryas of the Phyllomedusinae subfamily were studied by sequence...
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