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Bombesin was intracisternally administered to determine the effects on the neuronal activities of the dorsal column nuclei (DCN) of anesthetized rats. Although averaged afferent somatosensory transmission through 22 DCN neurons did not appear to be altered by bombesin (-1.11 ± 3.5%), 12 of them were actually augmented (+17.15 ± 2.7%) and 10 of them were suppressed (-26.15 ± 4.9%) during 40 min after...
The influence of peripheral somatostatin immunoneutralization on intravenous (IV) and intracerebroventricular (ICV) bombesin-induced inhibition of gastric acid secretion (GAS) was investigated with the somatostatin monoclonal antibody, CURE.S6, in rats. The somatostatin antibody, injected IV in conscious rats with a chronic gastric fistula and IV catheter, did not modify basal GAS, whereas in urethane-anesthetized...
STRYJEK-KAMINSKA, D., A. PIIPER, W. F. CASPARY AND S. ZEUZEM. Epidermal growth factor inhibits hormone- and fibroblast growth factor-induced activation of phospholipase C in rat pancreatic acini. PEPTIDES 16(1) 123-128, 1995. - Epidermal growth factor (EGF) inhibits cholecystokinin-octapeptide-stimulated amylase release and inositol 1,4,5-trisphosphate (1,4,5-IP 3 ) production in isolated...
Analogues of the amphibian neuropeptide, bombesin, and of the mammalian homologue, gastrin-releasing peptide, have been synthesized and their biological activity studied in small cell lung carcinoma and rat pancreatic acinar cells. The compounds are truncated sequences of the active tetradecapeptide BN(1-14) or GRP(20-27). Peptides were cyclized between position 5 or 7 and the carboxyl end of the...
Dual excitation microfluorimetry (Fura-2) was used to measure changes in intracellular calcium ([Ca 2+ ]i) in individual cultured guinea pig myenteric neurons. Bombesin (5-500 nM) induced concentration-dependent increases in [Ca 2+ ] i responses, with a maximal effect at 500 nM (56% of neurons responding, mean peak Ca 2+ response 244 ± 25 nM vs. basal...
Northern blot and RNAse protection assays previously failed to detect bombesin-like peptide (BLP) receptors in normal human lung tissue, but by RT/PCR cultured human bronchial epithelial (HBE) cells expressed all three BLP receptor subtypes, predominantly neuromedin B (NMB) receptor. By RT/PCR, we found expression of all three BLP receptor subtypes by human lung tissue and confirmed NMB receptor...
The anorectic effect of IP injection of amylin (1 μg/kg) was abolished by simultaneous IP injection of the amylin receptor antagonist calcitonin gene-related peptide-(8-37) [CGRP(8-37), 10 μg/kg]. The IP injection of pancreatic glucagon (400 μg/kg) at dark onset also reduced food intake in 24-h food-deprived rats, and this effect was also totally blocked by coadministration of CGRP(8-37)(10 μg/kg)...
Large quantities of gastrin-releasing peptide-like immunoreactivity (GRP-LI) are present in ovine pregnancy fluids (allantoic fluid > fetal plasma > esophageal fluid = amniotic fluid = urine > maternal plasma) and in term endometrium (60 ± 29 pmol g -1 ) and myometrium (4.5 ± 1.2 pmol g -1 ). The larger molecular size [greater than GRP(1-27)] of this GRP-LI entity...
Bombesin (BN) and its mammalian relatives, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been implicated in the control of food intake, and more recently systemic injections of BN have been shown to suppress need-free and sodium deficiency-induced salt (NaCl) intake. Postoral mechanisms that are activated by the ingestion of salt contribute to the termination of salt intake. The hypothesis...
Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bombesin-induced contractions were antagonized by SP antagonist. VIP-induced relaxation...
In the present study, we investigated the influence of blockade of the serotoninergic and histaminergic neurotransmitter system on the anorectic effect of IP-injected amylin in rats. In 12- or 24-h food-deprived rats, blockade of central and peripheral serotonin (5-HT) receptors with the 5-HT 1 and 5-HT 2 receptor antagonist metergoline (0.5 or 0.05 mg/kg, IP, respectively) did not...
Lutz, T. A., T. R. Pieber, B. Walzer, E. Del Prete and E. Scharrer. Different influence of CGRP(8-37), an amylin and CGRP antagonist, on the anorectic effects of cholecystokinin and bombesin in diabetic and normal rats. Peptides 18(5) 643-649, 1997.—Because previous studies had suggested that the anorectic effects of cholecystokinin (CCK) and bombesin (BBS) depend partly on the release of amylin or...
Ferris, H. A., R. E. Carroll, D. L. Lorimer and R. V. Benya. Location and characterization of the human GRP receptor expressed by gastrointestinal epithelial cells. Peptides 18(5) 663-672, 1997.—The exact location of normal gastrin-releasing peptide (GRP) receptor expression by epithelial cells lining the human gastrointestinal (GI) tract is not known; yet this receptor is found on upwards of 50%...
AU, C. L., B. J. CANNY, P. G. FARNWORTH AND A. S. GIRAUD.Bombesin regulation of adrenocorticotropin release from ovine anterior pituitary cells.PEPTIDES 18(7) 995–1000, 1997.—Mammalian members of the bombesin-like peptide family (gastrin releasing peptides; GRP) have been localized in the ovine median eminence and in hypophysial-portal blood, suggesting a role in the regulation of anterior pituitary...
Lutz, T. A., M. Senn, J. Althaus, E. Del Prete, F. Ehrensperger and E. Scharrer. Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats. Peptides 19(2) 309-317, 1998.-The area postrema/nucleus of the solitary tract (AP/NTS) region plays an important role in the control of food intake since it...
Aalto, Y., S. Forsgren, U. Kjorell, J. Bergh, L. Franzen and R. Henriksson. Enhanced expression of neuropeptides in human breast cancer cell lines following irradiation. PEPTIDES. 19(2) 231-239, 1998.-Previously, we have observed that the expression of the neuropeptides bombesin (BN-), the mammalian counterpart being gastrin-releasing peptide (GRP), and substance P (SP) in intact normal tissues, such...
Milusheva, E. A., N. I. Kortezova, Z. N. Mizhorkova, M. Papasova, D. H. Coy, A. Balint, E. S. Vizi and G. Varga. Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract. Peptides 19(3): 549-556, 1998.-Mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) are known to increase the motility of different segments...
We have previously shown that brief, vena caval infusion of gastrin-releasing peptide 1-27 (GRP), delivered shortly (5 min) after the end of the first spontaneous nocturnal meal, significantly prolongs the postprandial intermeal interval (IMI) without affecting the size of the subsequent meal in freely-feeding rats. In the present study, we tested whether varying the time at...
Bombesin (BN) injected to sodium depleted rats either centrally, particularly into the paraventricular nucleus (PVN) or peripherally by intraperitoneal (IP) route, exerts a potent inhibitory effect on the intake of 2% sodium chloride. To determine whether the area postrema (AP) and the lateral parabrachial nucleus (LPBN), which are known to be involved in the control of ingestive behavior, could be...
The present study was performed to determine whether low doses (10 or 40 ng) of bombesin microinjected into the amygdala could modify solid food intake. Forty ng of bombesin in 24 h deprived rats caused transient inhibition of food intake. This inhibitory effect was eliminated by prior bombesin antagonist treatment. A series of quantitative behavioral tests indicated that low doses of bombesin application...
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