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Novel sulfamide [-NHSO 2 NH-] linked dinucleotide analogues d(TnsnT) and d(TnsnA) have been synthesised from 3 - and 5 -amino nucleosides. Treatment of these amino nucleosides with catechol sulfate results in the formation of 2-hydroxyphenyl sulfamate esters which couple smoothly in good yields with either 5 - or 3 -amines of similar nucleosides. NMR studies showed that the 3 -sulfamide group results in a preferential C3 -endo (Northern) sugar conformation.