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Functional role of cellular prion protein (PrPc) has been hypothesized to be in metal homeostasis and providing cells with a superoxide dismutase (SOD)-like activity to escape damage by reactive oxygen species (ROS). PrPc interacts with a range of divalent metal ions and undergoes Cu 2+ as well as Zn 2+ -associated endocytosis, thereby maintaining homeostasis of these and other metal...
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