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Aldose reductase (AR) is a multi-functional AKR (AKR1B1) that catalyzes the reduction of a wide range of endogenous and xenobiotic aldehydes and their glutathione conjugates with high efficiency. Previous studies from our laboratory show that AR protects against myocardial ischemia–reperfusion injury, however, the mechanisms by which it confers cardioprotection remain unknown. Because AR metabolizes...
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