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Reactive oxygen species (ROS)-induced DNA double-strand breaks (DSBs) are a feature of cancer initiation. Recently, the cells of origin of ovarian high-grade serous carcinoma (HGSC) have been identified as secretory cells in fallopian tube fimbriae, which might be heavily exposed to ROS after ovulation. Establishing a sensitive detection method for measuring DSBs and the cell cycle in fallopian tube...
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