Major and trace element geochemistry including Sr–Nd–Pb–Hf isotopic data are presented for a representative sample suite of Late Devonian to Early Carboniferous plutonic and volcanic rocks from the Hugo Dummett deposit of the giant Oyu Tolgoi porphyry Cu–Au district in South Gobi, Mongolia. Sr and Nd isotopes (whole-rock) show restricted ranges of initial compositions, with positive εNdt mainly between +3.4 and +7.4 and ( 87 Sr/ 86 Sr)t predominantly between 0.7037 and 0.7045 reflecting magma generation from a relatively uniform juvenile lithophile-element depleted source. Previously dated zircons from the plutonic rocks exhibit a sample-averaged range of εHft values of +11.6 to +14.5. Depleted-mantle model ages of 420–830 (Nd) and 320–730Ma (zircon Hf) limit the involvement of pre-Neoproterozoic crust in the petrogenesis of the intermediate to felsic calc-alkaline magmas to, at most, a minor role. Pb isotopes (whole-rock) show a narrow range of unradiogenic initial compositions: 206 Pb/ 204 Pb 17.40–17.94, 207 Pb/ 204 Pb 15.43–15.49 and 208 Pb/ 204 Pb 37.25–37.64, in agreement with Sr–Nd–Hf isotopes indicating the dominance of a mantle component. All four isotopic systems suggest that the magmas from which the large Oyu Tolgoi porphyry system was generated originated predominantly from juvenile material within the subduction-related setting of the Gurvansayhan terrane.