Many sections of Paleoproterozoic greenstone belts in the Birimian of Ghana are found to have experienced subgreenschist- to greenschist-facies metamorphism. However, mineral-chemical and textural examinations in combination with conventional geothermobarometry of metapelites and amphibolites from the southern Kibi-Winneba belt suggest peak amphibolite-facies conditions of 500-610 o C at 4.5-6 kbar. This is in accordance with peak-metamorphic P-T estimates of 490-580 o C at 4-6 kbar for Birimian rocks of the southern Ashanti belt [Precambrian Res. 98 (1999) 11] and the northwestern Sefwi belt [Geol. Jahrbuch, in press]. Hydrothermal alteration and gold mineralization in this region apparently has occurred during retrograde greenschist-facies conditions at temperatures of 400-540 o C as indicated by the sulfide paragenesis arsenopyrite-pyrite (with lollingite inclusions) and arsenopyrite-pyrrhotite. These data suggest that alteration and lode-gold mineralization occurred under post-peak-metamorphic conditions.