FTIR spectra of acetylene have been studied in liquefied Ar, Kr, N 2 , CO and CO 2 in the range ~1000-9000cm - 1 . Width, position and absolute integral intensity of a set of fundamental and combination bands were determined. In the case of ν 3 band an effect of vibrational resonance interaction of Fermi-type has been taken into account and the position of non-perturbed ν 3 0 and (ν 2 +ν 4 +ν 5 ) 0 bands were evaluated in the solutions studied. Liquid to crystal state phase transition experiments, performed in Kr solutions, show reversible growth of self-associates when going to lower temperatures of C 2 H 2 doped solid Kr. The ν 3 (Σ u + ) C-H stretch band exhibits weak side shoulders in the case of CO and CO 2 solvents. New combination bands, attributed to ν 2 (C 2 H 2 )+ν 3 (CO 2 ), ν 3 (C 2 H 2 )+ν 3 (CO 2 ) and ν 1 (C 2 H 2 )+ν 3 (CO 2 ) simultaneous transitions due to vibrational excitation of both the interacting partners have been revealed in the region of ~4000-6000cm - 1 . Detecting the ν 3 (C 2 H 2 )+ν 3 (CO 2 ) combination band, which is forbidden in the frame of dipole approximation, suggests an appreciable role of mutual polarization due to dipole-quadrupole polarizability of molecular partners. The observed spectroscopic features are compared with the results of theoretical DFT/B3LYP and ab initio MP2 calculations utilizing the 6-311++G(3df,3pd) basis set, which predict weak heterodimer formation, with linear H-C≡C-H...C O and slipped parallelH-C≡C-HO-C-Ostructures being favored.