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Chemical agents such as porphyrins were found to be activated by ultrasound, producing significant antitumor effects. Hematoporphyrin (Hp) enhanced ultrasonically induced damage on sarcoma cells and shown a synergistic inhibitory effect on the tumor growth in combination with ultrasound at 2 MHz. Recently, other types of porphyrins such as protoporphyrin were also found to have such sonodynamic...
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