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Acute hypoxia depolarizes carotid body chemoreceptor (glomus) cells and elevates intracellular Ca 2+ concentration ([Ca 2+ ] i ). Recent studies suggest that AMP-activated protein kinase (AMPK) mediates these effects of hypoxia by inhibiting the background K + channels such as TASK. Here we studied the effects of modulators of AMPK on TASK activity in cell-attached...
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