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This review developed from the discussions of two meetings, one was held in London, U.K. and the subsequent one, in San Francisco, U.S.A.; both were sponsored by The Foundation Fighting Blindness. The participants represented members of the U.K. and U.S.A. clinical and scientific communities, members of The Foundation Fighting Blindness and International Retinitis Pigmentosa Association advisory boards.
We have examined how transplantation of an RPE cell line to the subretinal space of RCS rats affects the distribution of synaptic connectivity markers in the outer plexiform layer of the retina. Using markers of pre- and post-synaptic profiles (bassoon and synaptophysin as presynaptic markers and mGluR6 for postsynaptic profiles) we found that the normal orderly patterns seen between photoreceptors...
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