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The effect of a caspase-3 inhibitor on N -methyl- N -nitrosourea (MNU)-induced retinal degeneration was investigated. Sixty mgkg−1MNU was given intraperitoneally to 50 day old female Sprague–Dawley rats, and 4000ng Ac-DEVD-CHO, a caspase-3 inhibitor, was injected intravitreally twice at 0 and 10hr after MNU. In both peripheral and central retina, an apoptotic index of the photoreceptor cells 24hr...
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