The generation of a streaming current is one of the processes taking place inside the chromatographic column and is inseparably linked with the other processes. It guarantees that simultaneous monitoring of the chemical composition of the column effluent and of the streaming current generated by the liquid mobile phase inside the separation column supplies perfectly consistent and complementary experimental data on the chromatographic (mass) and electrokinetic (charge) aspects of the processes taking place on the column. Adsorption is often the elementary step determining the result of the chromatographic separation and close analogy exists between chromatographic and electrokinetic effects in chromatographic separation systems designed and working properly. Chemisorption of a compound on the column filling results in mass and charge effects which are drastically different from each other as well as from the effects observed at reversible adsorption of a compound on the column filling. These facts allow easy discrimination of adsorption and chemisorption processes in solid-liquid systems. A family of measurements, based on the liquid chromatography-streaming current hyphenation is possible.