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The replication of human immunodeficiency virus (HIV) in CD4+ T-cells is strongly dependent upon the state of activation of infected cells. Infection of sub-optimally activated cells is believed to play a critical role in both the transmission of virus and the persistence of CD4+ T-cell reservoirs. There is accumulating evidence that HIV can modulate signal-transduction pathways in a manner that may...
The precise relationship between the length of the 3′ poly(A) tail and the replication and infectivity of poliovirus RNA was examined in this study. With both poly(A) 11 and poly(A) 12 RNAs, negative-strand synthesis was 1–3% of the level observed with poly(A) 80 RNA. In contrast, increasing the length of the poly(A) tail from (A) 12 to (A) 13 resulted in about...
Poliovirus 2A pro is required for the inhibition of host cell protein synthesis and efficient viral replication. We investigated the role of 2A pro in regulating viral RNA stability, translation and replication in HeLa S10 reactions. The protease activity of 2A pro or its polyprotein precursors, 2AB or P2, was required to increase the stability of viral RNA and prolong translation...
Adenoviruses with deletion of E1b gene can selectively replicate in cancer cells. The underlying mechanisms in tumor-selective replication of E1b-deleted adenoviruses are insufficiently understood. Identifying genes with altered expression patterns caused by the E1B proteins in virus-infected cells will further increase our understanding of E1B functions and provide insight into the tumor-selective...
Hepadnaviruses establish chronic liver infections, but the mechanisms of persistence and immune evasion are poorly understood. We previously found that the duck hepatitis B virus (DHBV) and hepatitis B virus reverse transcriptases (P protein) unexpectedly accumulate in the cytoplasm where they could affect function(s) beyond viral DNA synthesis, such as gene expression. Therefore, we measured effects...
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