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To determine the contribution of IL-1, TNF-α and IL-17 on AP-1, NF-κB and Egr-1 activation in cytokine induced bone destruction as observed in rheumatoid arthritis, we investigated the effect of these pro-inflammatory cytokines used alone or in combination on transcription factor activation in osteoblast-like ROS 17/2.8 cells. The effects of each cytokine were measured by RT-PCR and immunocytochemistry...
The present study was aimed to investigate the anti-arthritic effect of majoon ushba (MU) and its underlying mechanism in adjuvant induced arthritis (AIA) rats. Arthritis was induced by intradermal injection of complete freund’s adjuvant (0.1ml) into the right hind paw of the Wistar albino rats. MU (1000mg/kg/b.wt) and methotrexate (3mg/kg/b.wt) were administered from day 11 to day 18th for 8days...
Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) play a crucial role in RA through producing inflammatory cytokines and proteases which could cause cartilage destruction. We showed previously that elevated expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) in RA synovium correlated significantly with the severity of synovitis and the number of infiltrated inflammatory...
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