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Fumonisin B 1 (FB 1 ), a mycotoxin, is a potent inhibitor of ceramide synthase, and produces organ-, species-, and even gender-specific toxic responses in animals. The hepatotoxic response of FB 1 in mice involves accumulation of free sphingoid bases and induction of inflammatory cytokines including tumor necrosis factor α (TNFα). The FB 1 -induced hepatotoxic responses...
Transforming growth factor (TGF)β inhibits normal epithelial cell proliferation. A decreased expression of TGFβ receptors (TβR) has been associated with loss of TGFβ sensitivity and enhanced tumor progression in many types of cancer. Although lung cancer is one of the leading causes of cancer death, a comparative analysis of TβR mRNA and protein expression in non-small-cell (NSC) lung tumors has not...
The purpose of this study was to determine whether apoptosis in placenta was affected by IFNγ, which can induce abortion, and whether the effect of IFNγ on apoptosis resulted from an intrinsic program of apoptosis, which was regulated by Bcl-2 and Bax. DNA fragmentation analysis indicated that cleavage of DNA into 180 bp and its polymers were recognized in placenta in control and IFNγ treated groups...
Interferon-β (IFN-β) protein and activity can be detected by enzyme immunoassays and biological assays. However, precise quantification of low IFN-β mRNA concentrations, which is advantageous for investigating IFN-β gene expression in small tissue samples or during the early stage of a virus infection, remains a challenge. Therefore, we established a quantitative real-time PCR (qPCR) for IFN-β and...
Although the etiology of Behcet's disease (BD) still remains uncertain, various immune abnormalities have been implicated in BD. We studied cytokine production in patients with active and inactive BD, and evaluated the effect of treatment with infliximab (anti-TNF-α antibody) on disease activity and cytokine production by the ELISPOT assay. The numbers of cells spontaneously secreting IFN-γ, IL-12,...
The polymorphism at position 25 of the gene encoding transforming growth factor-β1 (TGF-β1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-β1 production. The homozygous genotype (Arg25Arg) is associated with higher TGF-β1 production than the heterozygous (Arg25Pro) genotype. Therefore, the possible involvement of this genetic...
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