To determine whether severe stress events and more frequent use of stress-management behaviors among men with human immunodeficiency virus (HIV) infection are associated with more desirable nutrition-related parameters. Data on sociodemographic variables, severe stress events, stress management, and nutrition-related parameters were obtained from interviews, venipunctures, medical record reviews, bioelectrical impedance analysis, and questionnaires from the baseline wave of a three-wave longitudinal study. The sample consisted of 226 men with HIV who were attending one of three infectious disease clinics. Multivariable linear and logistic regression were used to determine the association of severe stress events and mean stress-management subscore with nutrition-related parameters when controlling for CD4 + T cells, age, income, and race. Men with more severe stress events were more likely to experience nausea (odds ratio=1.4, P<.01) and change in appearance (odds ratio=1.25, P=.02). Men who more frequently used stress-management behaviors had a lower body mass index (β=–1.14, P=.02), lower percent body fat (β=–1.12, P=.05), more frequent use of nutritional-health promoting behaviors (β=.52, P<.01), and were less likely to experience a change in appearance (odds ratio=0.63, P=.05) and have unintentional weight loss (odds ratio=0.54, P=.05). Men with more severe stress events are more likely to experience undesirable symptoms that could adversely influence nutritional health. More frequent use of stress-management behaviors may provide a coping mechanism for stress associated with HIV and ultimately improve nutritional health of men with HIV/acquired immunodeficiency syndrome.