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Testicular germ cell cancer is preceded by a pre-invasive stage called carcinoma-in-situ (CIS). The majority, if not all cases of CIS will progress into invasive cancer. Today, the only reliable way of diagnosing CIS is by performing open testicular biopsy. There is an ongoing search for non-invasive techniques for diagnosing early testicular neoplasia. The possibility of using ultrasound of the testis...
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