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Metallothionein (MT)-III isoform is a brain metal-binding protein that, like the MT-I+II isoform, binds zinc with high affinity. In the young-adult age, MT-III isoform increases during transient stress while MT-I+II isoform decreases, suggesting compensatory phenomena between the two isoforms and a protective role of MT-III against oxidative damage. This role may be questioned during ageing, because...
To understand graft rejection in cell based therapies for brain repair we have quantified IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ and TNF-α mRNA levels using real-time PCR, at days 4, 14, and 42 post-transplantation, in rats engrafted with syngeneic, allogeneic, concordant and discordant xenogeneic neural tissues. In addition, in the discordant xenografts immunohistochemistry and in situ hybridization...
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