Brain Research Bulletin

Items from 1 to 20 out of 28 results

article

Deprivation and denervation differentially affect zinc-containing circuitries in the barrel cortex of mice

Artur Czupryn, Jolanta Skangiel-Kramska

Brain Research Bulletin > 2001 > 55 > 2 > 287-295

In the neocortex, a population of glutamatergic synapses contains chelatable zinc that is released upon depolarization. The present study compares the effect of chronic tactile deprivation and vibrissectomy performed at different postnatal ages on the synaptic zinc distribution in the mouse barrel cortex. We found that a chronic unilateral tactile deprivation resulted in an increase of synaptic zinc...

article

Roles of the metallothionein family of proteins in the central nervous system

Juan Hidalgo, Michael Aschner, Paolo Zatta, Milan Vašák

Brain Research Bulletin > 2001 > 55 > 2 > 133-145

Metallothioneins (MTs) constitute a family of proteins characterized by a high heavy metal [Zn(II), Cu(I)] content and also by an unusual cysteine abundance. Mammalian MTs are comprised of four major isoforms designated MT-1 trough MT-4. MT-1 and MT-2 are expressed in most tissues including the brain, whereas MT-3 (also called growth inhibitory factor) and MT-4 are expressed predominantly in the central...

article

Antidepressant-like properties of zinc in rodent forced swim test

Bernadeta Kroczka, Piotr Branski, Agnieszka Palucha, Andrzej Pilc, more

Brain Research Bulletin > 2001 > 55 > 2 > 297-300

The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test. Zinc (ZnSO ₄ ) in a dose of 30 mg/kg and imipramine (30 mg/kg), reduced the immobility time in the forced swim test in both species. Moreover, combined treatment in this test with zinc and imipramine at their ineffective doses (1 and 5 mg/kg, respectively) induced...

article

Neurotoxicity and molecular effects of methylmercury

Anna F. Castoldi, Teresa Coccini, Sandra Ceccatelli, Luigi Manzo

Brain Research Bulletin > 2001 > 55 > 2 > 197-203

The neurotoxicity of high levels of methylmercury (MeHg) and the high susceptibility of the developing brain are well established both in humans and experimental animals. Prenatally poisoned children display a range of effects varying from severe cerebral palsy to subtle developmental delays. Still unknown is the lowest dose that impairs neurodevelopment. The primary source of human exposure is the...

article

Immunostaining of calmodulin and aluminium in Alzheimer's disease-affected brains

Beka Solomon, Rela Koppel, J. Jossiphov

Brain Research Bulletin > 2001 > 55 > 2 > 253-256

Previous in vitro studies have shown that Al ³ ⁺ binds to calmodulin, inducing alterations in its capability to interact with target proteins, accompanied by loss of immunological recognition by its conformational specific monoclonal antibody CAM1. In spite of the wealth of data of calmodulin action in vitro, little information is available on the possible involvement of this protein in...

article

Serum concentrations of some metals and steroids in patients with chronic fatigue syndrome with reference to neurological and cognitive abnormalities

S.J. van Rensburg, F.C.V. Potocnik, T. Kiss, F. Hugo, more

Brain Research Bulletin > 2001 > 55 > 2 > 319-325

Chronic fatigue syndrome is defined by the Atlanta Centers for Disease Control (Atlanta, GA, USA) as debilitating fatigue lasting for longer than 6 months. Symptoms include disturbances of cognition. Certain factors have in the past been shown to influence cognition, including metals such as aluminum, iron, and zinc; and steroids such as dehydroepiandrosterone. In the present study, concentrations...

article

Immune-endocrine status and coeliac disease in children with Down's syndrome: relationships with zinc and cognitive efficiency

Federico Licastro, Rossella Antonietta Mariani, Giacomo Faldella, Emilio Carpenè, more

Brain Research Bulletin > 2001 > 55 > 2 > 313-317

Immune defects, thyroid abnormalities, plasma zinc levels, and the presence of gastrointestinal disease were investigated in 43 children with Down's syndrome (DS). Peripheral T lymphocytes with the phenotype of helper cells or cluster of differentiation 4 (CD4) were decreased. Circulating activated T cells (CD3/HLA-DR-positive cells) and large granular lymphocytes (CD16/CD56 positive cells) were increased...

article

Effect of temperature on postanoxic, potentially neurotoxic changes of plasma pH and free iron level in newborn rats

Michał Caputa, Justyna Rogalska, Anna Nowakowska

Brain Research Bulletin > 2001 > 55 > 2 > 281-286

In asphyxiated newborns, iron, released from heme and ferritin and deposited in the brain, contributes to neurodegeneration. Because hypothermia provides neuroprotection, newborn mammals, showing reduced body temperature, might avoid iron-mediated neurotoxicity. However, hypothermia leads to acidosis, which induces hyperferremia. Therefore, we decided to study the effects of body temperature on plasma...

article

Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water

Trond Peder Flaten

Brain Research Bulletin > 2001 > 55 > 2 > 187-196

Aluminium (Al) is clearly a powerful neurotoxicant. Considerable evidence exists that Al may play a role in the aetiology or pathogenesis of Alzheimer's disease (AD), but whether the link is causal is still open to debate. This paper reviews the epidemiological evidence linking Al and AD. Nine out of 13 published epidemiological studies of Al in drinking water and AD have shown statistically significant...

article

The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency

N.Q. Liu, Q. Xu, X.L. Hou, P.S. Liu, more

Brain Research Bulletin > 2001 > 55 > 2 > 309-312

Cretinism is a disease characterized by neurological defects associated with severe iodine deficiency. In a rat model of severe iodine deficiency, we investigated the distribution pattern of trace elements (iodine [I], selenium [Se], and bromine [Br] in brain tissue samples; potassium [K], calcium [Ca], manganese [Mn], iron [Fe], copper [Cu], zinc [Zn], rubidium [Rb], and lead [Pb] in erythrocytes)...

article

Zinc-bound metallothioneins as potential biological markers of ageing

Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Mario Muzzioli, more

Brain Research Bulletin > 2001 > 55 > 2 > 147-153

Metallothioneins (MTs) (I+II) play pivotal roles in metal-related cell homeostasis because of their high affinity for metals forming clusters. The main functional role of MTs is to sequester and/or dispense zinc participating in zinc homeostasis. Consistent with this role, MT gene expression is trascriptionally induced by a variety of stressing agents to protect cells from reactive oxygen species...

article

Metals and the brain: from neurochemistry to neurodegeneration

Paolo Zatta

Brain Research Bulletin > 2001 > 55 > 2 > 123-124

article

Effects of AlCl ₃ on toad skin, human erythrocytes, and model cell membranes

M. Suwalsky, B. Ungerer, F. Villena, B. Norris, more

Brain Research Bulletin > 2001 > 55 > 2 > 205-210

Aluminum, a very abundant metal, could play a toxic role in several pathological processes, including neurodegeneration. Although the effects of Al(III) on biological membranes have been extensively described, direct information concerning the molecular basis of its biological activity is rather scanty. To examine aluminum challenges on cell membranes, various concentrations of AlCl ₃ in aqueous...

article

The response of neurones and glial cells to elevated copper

Nicole T. Watt, Nigel M. Hooper

Brain Research Bulletin > 2001 > 55 > 2 > 219-224

Defective copper excretion in Wilson's disease can result in increased neurological copper concentrations. This is thought to occur following exposure to increased circulating copper released from necrotic hepatocytes in a saturated liver. BU17 human glioma cells and SH-SY5Y human neuroblastoma cells were exposed to media supplemented with copper in the range 0-250 μM for periods up to 48 h to investigate...

article

Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases

Daniel Strausak, Julian F.B. Mercer, Hermann H. Dieter, Wolfgang Stremmel, more

Brain Research Bulletin > 2001 > 55 > 2 > 175-185

Copper is an essential element for the activity of a number of physiologically important enzymes. Enzyme-related malfunctions may contribute to severe neurological symptoms and neurological diseases: copper is a component of cytochrome c oxidase, which catalyzes the reduction of oxygen to water, the essential step in cellular respiration. Copper is a cofactor of Cu/Zn-superoxide-dismutase which plays...

article

The effects of sodium arsenite exposure on behavioral parameters in the rat

V.M. Rodrı́guez, L. Carrizales, M.E. Jiménez-Capdeville, L. Dufour, more

Brain Research Bulletin > 2001 > 55 > 2 > 301-308

Arsenic is a metalloid widely present in the environment. It is found in well water, soil, and air, and is also released from mining residues and industrial debris, among other anthropogenic sources. It has been previously reported that the content of catecholamines in striatum, hippocampus, and other cerebral regions changes in mice and rats exposed to arsenic. Few studies have examined behavioral...

article

Aluminium incorporation into the brain of rat fetuses and sucklings

Sakae Yumoto, Hisao Nagai, Hiroyuki Matsuzaki, Hiroshi Matsumura, more

Brain Research Bulletin > 2001 > 55 > 2 > 229-234

Aluminium is highly neurotoxic and inhibits prenatal and postnatal development of the brain in humans and experimental animals. However, the incorporation of aluminium into the brain of fetuses and sucklings during gestation and lactation has not been well clarified because aluminium lacks a suitable isotope for a tracer experiment. In this study, we used ² ⁶ Al (a radioisotope of aluminium...

article

Enhanced brain regional lipid peroxidation in developing rats exposed to low level lead acetate

J. Villeda-Hernández, R. Barroso-Moguel, M. Méndez-Armenta, C. Nava-Ruı́z, more

Brain Research Bulletin > 2001 > 55 > 2 > 247-251

Neurotoxicity associated with lead exposure may be the result of a series of small perturbations in brain metabolism, and, in particular, of oxidative stress. Some studies have suggested a lead-induced enhancement on lipid peroxidation as a possible mechanism for some toxic effects of lead. However, there are no reports about the association between lipid peroxidation enhancement and brain lead content...

article

Iron and neurodegenerative disorders

Khristy J. Thompson, Shai Shoham, James R. Connor

Brain Research Bulletin > 2001 > 55 > 2 > 155-164

The brain shares with other organs the need for a constant and readily available supply of iron and has a similar array of proteins available to it for iron transport, storage, and regulation. However, unlike other organs, the brain places demands on iron availability that are regional, cellular, and age sensitive. Failure to meet these demands for iron with an adequate supply in a timely manner can...

article

Copper and prion disease

David R. Brown

Brain Research Bulletin > 2001 > 55 > 2 > 165-173

The prion protein is a cell surface glyco-protein expressed by neurones. Its function has remained elusive until it was recently shown to be a copper binding protein. There is now strong evidence that the prion protein has a role in normal brain copper metabolism. Prion protein expression alters copper uptake into cells and enhances copper incorporation into superoxide dismutase. Furthermore the prion...

Number:
2
Volume:
55
Year:
2001

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Keywords

ALZHEIMER'S DISEASE (6)
NEURODEGENERATION (4)
NEUROTOXICITY (4)
ALUMINUM (3)
COPPER (3)
OXIDATIVE STRESS (3)
ZINC (3)
IRON (2)
LOCOMOTOR ACTIVITY (2)
METALS (2)
NEUROPROTECTION (2)
RAT (2)
2 6 AL (1)
3-NITROPROPIONIC ACID (1)
ACCELERATOR MASS SPECTROMETRY (1)
ACETYLCHOLINE (1)
ACIDOSIS (1)
ACONITASE (1)
ALUMINIUM TOXICITY (1)
AMYOTROPHIC LATERAL SCLEROSIS (1)
ANAPYREXIA (1)
ANTACIDS (1)
ANTHRANILIC ACID (1)
ANTIOXIDANT DEFENSE (1)
APOPTOSIS (1)
ARSENIC (1)
BEHAVIOR (1)
BIOAVAILABILITY (1)
BRAIN (1)
BRAINSTEM (1)
CALCIUM (1)
CENTRAL NERVOUS SYSTEM (1)
CHOLESTEROL (1)
CHRONIC FATIGUE (1)
CNS (1)
COGNITION (1)
CONFORMATIONAL MONOCLONAL ANTIBODIES (1)
CRETINISM (1)
DEGENERATION (1)
DHEAS (1)
ENDOCRINE SYSTEM (1)
EPIDEMIOLOGY (1)
EXCITOTOXICITY (1)
FEVER (1)
FLUORIDE (1)
FORCED SWIM TEST (1)
FREE RADICAL GENERATION (1)
GABA (1)
GESTATION (1)
GLIA (1)
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (1)
HEAVY METALS (1)
HIPPOCAMPUS (1)
HYPERFERREMIA (1)
IMMUNE ASSET (1)
IMMUNE SYSTEM (1)
IMMUNORECOGNITION (1)
IN SITU END LABELING (1)
INFLAMMATION (1)
INTESTINAL ALTERATIONS (1)
IRON HOMEOSTASIS (1)
IRON PROTEINS (1)
IRON RELEASE (1)
LEAD INTOXICATION (1)
LEARNING (1)
LIPID PEROXIDATION (1)
MENKES (1)
METAL-THIOLATE COMPLEXES (1)
METALLOTHIONEIN ISOFORMS (1)
MICE (1)
MICRODIALYSIS (1)
MICROTUBULES (1)
MITOCHONDRIAL MEMBRANE POTENTIAL (1)
MONOAMINES (1)
MOUSE (1)
NERVOUS SYSTEM (1)
NEURODEGENERATIVE DISEASES (1)
NEUROTRANSMISSION (1)
NMDA RECEPTORS (1)
NUCLEAR ANALYTICAL TECHNIQUES (1)
OXIDATIVE DAMAGE (1)
PARKINSON'S DISEASE (1)
PERINATAL ASPHYXIA (1)
PHOSPHOLIPID BILAYER (1)
PLASMA ZINC (1)
PLASTICITY (1)
POST-ROTATORY-NYSTAGMUS (1)
PRION-RELATED PROTEIN (PRP) (1)
QUINOLINIC ACID (1)
RATS (1)
RODENTS (1)
SILICON (1)
SOMATOSENSORY CORTEX (1)
STRUCTURE (1)
SULPHYDRYL GROUPS (1)
SUPEROXIDE DISMUTASE (1)
SYNAPTIC ZINC (1)
THYROID FUNCTION (1)
TRACE ELEMENTS (1)
TRYPTOPHAN METABOLITES (1)
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Brain Research Bulletin

Deprivation and denervation differentially affect zinc-containing circuitries in the barrel cortex of mice

Roles of the metallothionein family of proteins in the central nervous system

Antidepressant-like properties of zinc in rodent forced swim test

Neurotoxicity and molecular effects of methylmercury

Immunostaining of calmodulin and aluminium in Alzheimer's disease-affected brains

Serum concentrations of some metals and steroids in patients with chronic fatigue syndrome with reference to neurological and cognitive abnormalities

Immune-endocrine status and coeliac disease in children with Down's syndrome: relationships with zinc and cognitive efficiency

Effect of temperature on postanoxic, potentially neurotoxic changes of plasma pH and free iron level in newborn rats

Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water

The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency

Zinc-bound metallothioneins as potential biological markers of ageing

Metals and the brain: from neurochemistry to neurodegeneration

Effects of AlCl ₃ on toad skin, human erythrocytes, and model cell membranes

The response of neurones and glial cells to elevated copper

Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases

The effects of sodium arsenite exposure on behavioral parameters in the rat

Aluminium incorporation into the brain of rat fetuses and sucklings

Enhanced brain regional lipid peroxidation in developing rats exposed to low level lead acetate

Iron and neurodegenerative disorders

Copper and prion disease

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