In this paper, the effects of the La doping method on the microstructure and mechanical properties of Mo alloys were investigated. The powders were fabricated by the industrial produced pure Mo powder, solid–solid doping method (S–S), solid–liquid doping method (S–L) and liquid–liquid doping method (L–L), respectively. In addition, the powders were processed into sintered Mo, rotary swaged Mo and Mo wire. The results indicated that the powders became finer and the grain boundaries of the Mo prepared by S–L(S–L Mo) and L–L (L–L Mo) had the ability to migrate and wrap the La 2 O 3 particles into the grain interior during sintering with the addition of La. The tensile strength and elongation of the rotary swaged L–L Mo were the highest and the tensile elongation was raised to 42% at room temperature. Moreover, the L–L Mo wire had the highest tensile strength after the treatment at all the annealing temperatures and the S–L and L–L Mo wire possessed higher recrystallization temperature than the Mo prepared by S–S (S–S Mo) and pure Mo wire obtained.