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Disrupted HCO3– transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF.In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults.In neonates with CF, nasal ASL (pH5.2±0.3) was more acidic than in non-CF neonates (pH6.4±0.2). In contrast,...
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