Conceptual designs of accelerator driven systems (ADS) that utilize thorium fuel as blanket and reprocessed fuel as seed for fission reaction in order to transmute the transuranic elements in spent nuclear fuel and produce energy from thorium utilization was proposed. In order to analyze the TRU transmutation performance of the system while the safety margin during the operation is satisfied, a parametric survey is done in this study. The impact of minor actinide (MA) amount and the reactor size on transmutation efficiency and safety characteristics of the ADS is investigated using MCNPX code using the ENDF/B-VII. As the results, with increasing MA content, TRU transmutation rate is increased while void reactivity of the system becomes less negative. Besides, increasing the core size by introducing more thorium and reprocessed fuel assemblies into the system reduces the TRU transmutation rate and reactivity swing due to burnup of the system. In order to match the efficient transmutation purpose and safety features during operation, higher MA content is suggested to introduce into the system.