The recent epistemological and cognitive studies concentrate on the concept of abduction, as a means to originate and refine new ideas. Traditional cognitive science and computational accounts concerning abduction aim at illustration discovery and creativity processes in terms of theoretical and “internal” aspects, by means of computational simulations and/or abstract cognitive models. I will illustrate in this paper that some typical internal abductive processes are involved in scientific reasoning and discovery (for example through radical innovations). Nevertheless, especially concrete manipulations of the external world constitute a fundamental passage in science: by a process of manipulative abduction it is possible to build prostheses (epistemic mediators) for human minds, by interacting with external objects and representations in a constructive way. In this manner it is possible to create implicit knowledge through doing and to produce various opportunity to find, for example, anomalies and fruitful new risky perspectives. This kind of embodied and unexpressed knowledge holds a key role in the subsequent processes of scientific comprehension and discovery.