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Frontotemporal dementia (FTD) is classically considered to be a neurodegenerative disease with cortical changes. Recent structural imaging findings, however, highlight that subcortical and in particular striatal regions are also affected in the FTD syndrome. The influence of striatal pathology on cognitive and behavioural changes in FTD is virtually unexplored. In the current study we employ the Weather...
The recently discovered hexanucleotide repeat expansion, C9ORF72, has been shown to be among the most common cause of familial behavioural variant frontotemporal dementia (bvFTD) and to be present in a significant minority of apparently sporadic cases. While mounting evidence points to prominent episodic memory dysfunction in bvFTD cases, recent reports have also suggested an amnestic profile in C9ORF72...
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