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Dysregulation of the endothelin axis has been implicated in the progression of prostate cancer; thus providing a potential therapeutic target. Atrasentan is a potent, selective, endothelin-A (ET A ) receptor antagonist that has been shown to block the mitogenic, anti-apoptotic, and bone-remodelling activity of endothelin-1 (ET-1) in pre-clinical studies. Orally bioavailable, with a half-life...
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