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Thiamethoxam (TMX) and clothianidin (CLO) are neonicotinoids insecticides. The main characteristic of these pesticides is their agonist action on nicotinic acetylcholine receptors (nAChRs). In the present work it was studied and characterized the effects of TMX and CLO, in different concentrations, on dopaminergic system of rat striatum using in vivo brain microdialysis coupled to HPLC-EC. Intrastriatal...
Paraquat (PQ) is a strong redox agent that contributes to the formation of reactive oxygen species (ROS) and induces toxicity of the nigrostriatal dopaminergic system. In this study, we investigated the effect of PQ on the dopaminergic system of four striatal subregions. Male C57BL/6 mice (aged 7 weeks and 23–25g) were used for this study. The mice were administrated with normal saline or PQ (10mg/kg...
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