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Within the context of safety assessment of ''social chemicals'' such as drugs, agrochemicals, major food additives and environmental chemicals, food flavors have conventionally been perceived to be of relatively low priority. The growing aspiration to achieve a ''globally recognized list of flavors'' and the necessity to achieve some degree of consensus as to the procedures to be used for their safety...
Re-evaluations of large prominent studies, e.g. the ED01 study and N-nitrosodiethylamine, unequivocally have demonstrated that thresholds exist for carcinogenicity when the dose-response curves for animal studies done at high doses are calculated according to fundamental principles of chemistry. This requires dose to be on a logarithmic scale and percent tumors on a linear scale. Fifteen compounds...
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