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Purpose: To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases.Methods and Materials: Adults with cerebral or cerebellar solitary non-brainstem tumors =< 40 mm in maximum diameter were eligible. Initial radiosurgical doses were 18 Gy for tumors =< 20 mm, 15 Gy for those 21-30 mm, and...
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