Forty elderly persons with mental retardation were assessed by their care providers on a modified version of the Short Informant Questionnaire on Cognitive Decline in The Elderly (IQCODE), an instrument designed to quantify cognitive decline in elderly people in the general population. They were also assessed for IQ, aberrant behavior, and current mental status; test-retest and interrater reliability were evaluated as well. Internal consistency, as assessed by coefficient alpha, was moderately high (α = .86). Test-retest reliability was mediocre and interrater reliability levels did not reach statistical significance. The Short IQCODE was not correlated with a variety of demographic features or with behavior ratings, showing evidence of divergent validity. However, the Short IQCODE was only weakly (nonsignificantly) correlated with a measure of current mental status, which challenges its concurrent validity. The Short IQCODE probably needs to be modified further for satisfactory psychometric performance in people with mental retardation. However, some features of this study may have resulted in suboptimal estimates of the Short IQCODE s psychometric characteristics.