The purpose of this pilot study was to assess emergency nurses' knowledge of evidence-based ischemic stroke care.A descriptive, correlational design was used. Emergency nurses (N = 20) working in 2 hospitals in the Mid-Atlantic region completed a 10-item multiple choice test on evidence-based ischemic stroke care.Test scores ranged from 30% to 90%, with a mean of 53% (SD = 12.93) on a scale of 0 to 100%. Forty-five percent (N = 9) of respondents indicated that they read literature on evidence-based ischemic stroke care within the previous 12 months. Respondents who read literature on evidence-based ischemic stroke care had a significantly higher mean test score (P = .04) than did respondents who did not read any literature on evidence-based ischemic stroke care. Only 15% (N = 3) of respondents reported that they had participated in continuing education on evidence-based ischemic stroke care within the previous 12 months. In addition, there was a significant correlation (P = .02) between number of years worked in emergency nursing as a registered nurse and test scores. Nurses with more years experience in emergency nursing had higher test scores.Overall, emergency nurses demonstrated a knowledge deficit in evidence-based ischemic stroke care. The majority of nurses had not participated in continuing education on evidence-based ischemic stroke care within the previous 12 months. Nurses should be provided with evidence-based education on ischemic stroke care and opportunities to participate in continuing education.