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Objective: To determine the value of a biomedical system dynamics (BMSD) approach for optimization of anemia management in long-term hemodialysis patients because elevated hemoglobin levels and high doses of erythropoiesis-stimulating agents (ESAs) may negatively affect survival in this population. Patients and Methods: A model of erythropoiesis and its response to ESAs on the basis of a BMSD method...
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