Response surface methodology (RSM) was used to analyze biomass production of ten freshwater and marine microalgae cultivated on eleven different media, under varying concentrations of both CO 2 and N-source to foster development of microalgae sequestering of CO 2 (MSCO 2 ). Experimental and literature data on biomass production were used. Modeling results indicate that microalgae sequestering of CO 2 is feasible over wide range of CO 2 and N concentrations and under both high and low ionic strength. Microalgae sequestering of CO 2 could become a profitable industry that would help mitigate global warming (GLW) and probably, enable environmentally neutral utilization of fossil fuels until their full replacement by alternative energy sources.